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Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. The structure of PEG is (note the repeated element in parentheses):


PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.

Medical uses

PEG is the basis of a number of laxatives (e.g., macrogol-containing products, such as Movicol and polyethylene glycol 3350, or SoftLax, MiraLAX,ClearLAX, or GlycoLax). Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy. The preparation is sold under the brand names GoLYTELY, GaviLyte C, NuLytely, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely, Softlax, Lax-a-Day, ClearLax and MoviPrep. In the United States, MiraLAX and Dulcolax Balance are sold without prescription for short-term relief of chronic constipation. Miralax is currently FDA approved for adults for a period of seven days, and is not approved for children.[6] A 2007 comparison showed that patients suffering from constipation had a better response to PEG medications than to tegaserod.[7] These medications soften the fecal mass by osmotically drawing water into the GI tract. It is generally well tolerated, however, side effects are possible bloating, nausea, gas, and diarrhea (with excessive use).

When attached to various protein medications, polyethylene glycol allows a slowed clearance of the carried protein from the blood. This makes for a longer-acting medicinal effect and reduces toxicity, and allows longer dosing intervals. Examples include PEG-interferon alpha, which is used to treat hepatitis C, and PEGfilgrastim (Neulasta), which is used to treat neutropenia. It has been shown that polyethylene glycol can improve healing of spinal injuries in dogs.[8] One of the earlier findings, that polyethylene glycol can aid in nerve repair, came from the University of Texas (Krause and Bittner).[9] Polyethylene glycol is also commonly used to fuse B-cells with myeloma cells in monoclonal antibody production.

PEG is used as an excipient in many pharmaceutical products. Lower-molecular-weight variants are used as solvents in oral liquids and soft capsules, whereas solid variants are used as ointment bases, tablet binders, film coatings, and lubricants.

PEG is also used in lubricating eye drops.

Research for new clinical uses

  •     PEG, when labeled with a near-infrared fluorophore, has been used in preclinical work as a vascular agent, lymphatic agent, and general tumor-imaging agent by exploiting the Enhanced permeability and retention effect (EPR) of tumors.
  •     High-molecular-weight PEG (e.g. PEG 8000) has been shown to be a dietary preventive agent against colorectal cancer in animal models.
  •     The Chemoprevention Database shows PEG is the most effective known agent for the suppression of chemical carcinogenesis in rats. Cancer prevention applications in humans, however, have not yet been tested in clinical trials.
  •     The injection of PEG 2000 into the bloodstream of guinea pigs after spinal cord injury leads to rapid recovery through molecular repair of nerve membranes.[14] The effectiveness of this treatment to prevent paraplegia in humans after an accident is not known yet.
  •     PEG is being used in the repair of motor neurons damaged in crush or laceration incidents in vivo and in vitro. When coupled with melatonin, 75% of damaged sciatic nerves were rendered viable.

Other uses
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Chemical uses

    Polyethylene glycol has a low toxicity and is used in a variety of products. The polymer is used as a lubricating coating for various surfaces in aqueous and non-aqueous environments.

    Since PEG is a flexible, water-soluble polymer, it can be used to create very high osmotic pressures (on the order of tens of atmospheres). It also is unlikely to have specific interactions with biological chemicals. These properties make PEG one of the most useful molecules for applying osmotic pressure in biochemistry and biomembranes experiments, in particular when using the osmotic stress technique.

    Polyethylene glycol is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.

    PEO (polyethylene oxide) can serve as the separator and electrolyte solvent in lithium polymer cells. Its low diffusivity often requires high temperatures of operation, but its high viscosity – even near its melting point – allows very thin electrolyte layers to be created. While crystallization of the polymer can degrade performance, many of the salts used to carry charge can also serve as a kinetic barrier to the formation of crystals. Such batteries carry greater energy for their weight than other lithium ion battery technologies.

    PEG has also been used to preserve objects that have been salvaged from underwater, as was the case with the warship Vasa in Stockholm,[18] the Mary Rose in England and the Ma'agan Michael Ship in Israel. It replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries. In addition, PEG is used when working with green wood as a stabilizer, and to prevent shrinkage.

    PEG is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.

    PEG derivatives, such as narrow range ethoxylates, are used as surfactants.

    PEG has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.

Biological uses

    PEG is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.

    Polymer segments derived from PEG polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.

    In microbiology, PEG precipitation is used to concentrate viruses. PEG is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.

    Gene therapy vectors (such as viruses) can be PEG-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect. The size of the PEG polymer has been shown to be important, with larger polymers achieving the best immune protection.

    PEG is a component of stable nucleic acid lipid particles (SNALPs) used to package siRNA for use in vivo.

    In blood banking, PEG is used as a potentiator to enhance detection of antigens and antibodies.

    When working with phenol in a laboratory situation, PEG 300 can be used on phenol skin burns to deactivate any residual phenol.

Commercial uses

    PEG is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).

    PEG is used in a number of toothpastes as a dispersant. In this application, it binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.

    PEG is also under investigation for use in body armor, and in tattoos to monitor diabetes.[26][27]

    In low-molecular-weight formulations (i.e. PEG 400), it is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.

    PEG is also one of the main ingredients in paintball fills, due to its thickness and flexibility. However, as early as 2006, some Paintball manufacturers began substituting cheaper oil-based alternatives for PEG.[citation needed]

    PEG is a major ingredient in e-liquid, used in electronic cigarettes. It is generally used as a 30%–50% proportion of the liquid that is vaporized. Its use is designed to give a smoother effect to the vaporizing action.[citation needed]

    PEG is also used as an anti-foaming agent in food[28] – its INS number is 1521 or E1521 in the EU.

Industrial uses

    Nitrate ester-plasticized polyethylene glycol is used in Trident II ballistic missile solid rocket fuel.

    Dimethyl ethers of PEG are the key ingredient of Selexol, a solvent used by coal-burning, integrated gasification combined cycle (IGCC) power plants to remove carbon dioxide and hydrogen sulfide from the gas waste stream.

    PEG has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.

    PEG is also used as a polymer host for solid polymer electrolytes. Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving PEG, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.

    PEG is used as a binder in the preparation of technical ceramics.